Selected Publications

Evidence for TGF-β1/Nrf2 Signaling Crosstalk in a Cuprizone Model of Multiple Sclerosis (2024) Guevara C, Vicencio SC, Pizarro IS, Villavicencio-Tejo F, Quintanilla RA, Astudillo P, Ampuero E, Varas R, Orellana JA, Ortiz FC. Antioxidants 2024, 13, 914. doi.org/10.3390/antiox13080914. PDF

A preclinical mice model of multiple sclerosis based on the toxin-induced double-site demyelination of callosal and cerebellar fibers (2024) Vejar S, Pizarro IS, Pulgar-Sepúlveda R, Vicencio SC, Polit A, Amador CA, Del Rio R, Varas R, Orellana JA, Ortiz FC. Biol Res. 2024 Jul 22;57(1):48. doi: 10.1186/s40659-024-00529-7. PDF

Electrophysiological Recordings of Oligodendroglia in Adult Mouse Brain Slices (2024) Guevara C, Varas R, Angulo MC, Ortiz FC. In: Kukley, M. (eds) New Technologies for Glutamate Interaction. Neuromethods, vol 2780. Humana, New York, NY. PDF

Neurodegeneration in Multiple Sclerosis: The Role of Nrf2-Dependent Pathways (2022) Maldonado P, Guevara C, Olesen M, Orellana JA, Quintanilla R, Ortiz FC. Antioxidants 11:1146. doi.org/10.3390/antiox11061146 PDF

Pannexin 1-based channels activity as a novel regulator of multiple sclerosis progression (2020) Ortiz FC and Puebla C. Neural Regen Res 15(1):65-66. doi:10.4103/1673-5374.264450. PDF

Neuroinflammation in Demyelinating Diseases: Oxidative Stress as a Modulator of Glial Cross-Talk. (2019) Varas R, Ortiz FC. Curr Pharm Des. 25(45):4755-4762. doi:10.2174/1381612825666191216125725.PDF

Neuronal activity in vivo enhances functional myelin repair (2019) Ortiz FC, Habermacher C, Graciarena M, Houry PY, Nishiyama A, Nait-Oumesmar B and Angulo MC. JCI insight.  21;5. pii: 123434. doi: 10.1172/jci.insight.123434. PDF

Connexin and Pannexin-Based Channels in Oligodendrocytes: Implications in Brain Health and Disease (2019) Vejar S, Oyarzún JE, Retamal MA*, Ortiz FC*, Orellana JA. Front Cell Neurosci 13:3 PDF

In vivo Optogenetic Approach to Study Neuron-Oligodendroglia Interactions in Mouse Pups (2018) Ortolani D, Manot-Saillet B, Orduz D, Ortiz FC*, Angulo MC*. Front Cell Neurosci. 12:477. PDF

Transient hypothyroidism favors oligodendrocyte generation providing functional remyelination in the adult mouse brain (2017) Remaud S, Ortiz FC, Perret-Jeanneret M, Aigrot MS, Gothié JD, Fekete C, Kvárta-Papp Z, Gereben B, Langui D, Lubetzki C, Angulo MC, Zalc B, Demeneix B. Elife 6. pii: e29996. doi: 10.7554/eLife.29996. PDF

Nonsynaptic junctions on myelinating glia promote preferential myelination of electrically active axons (2015) Wake H*, Ortiz FC*, Woo DH, Lee PR, Angulo MC, Fields RD. Nat Commun.6:7844. doi: 10.1038/ncomms8844. PDF

Alteration of synaptic connectivity of oligodendrocyte precursor cells following demyelination (2015) Sahel A*, Ortiz FC*, Kerninon C, Maldonado PP, Angulo MC, Nait-Oumesmar B. Front Cell Neurosci. 9:77. doi: 10.3389/fncel.2015.00077. PDF

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SPECIAL TOPIC ON MYELIN FORMING CELLS (Frontiers in Cellular Neuroscience, edited by Retamal M, Ortiz FC, Baraban M)

Physiology of Myelin Forming Cells, from Myelination to Neural Modulators